Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13422 | 0.96 | — | — | |
| Water SCHEMBL28235026 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL4261800 | 0.93 | HIF1A (0.33) | HIF1AMAPTPDE4AKDR | |
| Hydrochloric Acid SCHEMBL1002624 | 0.93 | — | — | |
| Methane SCHEMBL28109159 | 0.93 | — | — | |
| SCHEMBL2621589 | 0.84 | — | — | |
| Piperazine SCHEMBL27382581 | 0.83 | CXCR4 (0.41) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL20523142 | 0.83 | HIF1A (0.31) | HIF1AMAPTPDE4AKDR | |
| Hydrochloric Acid SCHEMBL18817103 | 0.82 | CXCR4 (0.35) | CXCR4SMN1; SMN2 | |
| Formic Acid SCHEMBL30170635 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112624965-A | Novel oxime derivative and application thereof in agriculture | 东莞市东阳光农药研发有限公司 | 2021-04-09 | — | — | CN | disclosed |
| WO-2002020437-A2 | BASIC COMPOUNDS CONTAINING TERTIARY AMIDES WITH ACTIVITY ON TACHYKININ RECEPTORS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MENARINI RICERCHE S.P.A. (IT) | 2002-03-14 | — | — | WO | disclosed |