Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 10/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12195758 | 0.82 | POLB (0.64) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1486262 | 0.81 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL1157478 | 0.80 | POLB (0.59) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4193485 | 0.78 | POLB (0.60) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7358310 | 0.78 | POLB (0.60) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7338297 | 0.78 | PDE4A (0.55) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1157367 | 0.77 | PDE4A (0.62) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1157433 | 0.77 | POLB (0.59) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1157362 | 0.77 | PDE5A (0.66) | POLBPDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1157756 | 0.77 | POLB (0.55) | POLBPDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | claimed |
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | disclosed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | disclosed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | disclosed |