Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7793438 | 1.00 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7793227 | 1.00 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7321654 | 0.91 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30683833 | 0.90 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7178035 | 0.89 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7786701 | 0.89 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7786696 | 0.89 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8057577 | 0.89 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7786788 | 0.89 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8041955 | 0.89 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | claimed |
| EP-0636026-A4 | — | — | 1995-02-22 | — | — | EP | claimed |
| EP-0636026-A1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-01 | — | — | EP | claimed |
| WO-1993019751-A1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | claimed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | disclosed |
| US-5605923-A | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |