Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | GLI1 | P08151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL3991283 | 1.00 | FFAR3 (0.39) | FFAR3LCKFYNGLI1 | |
| Acetic Acid SCHEMBL7210352 | 1.00 | FFAR3 (0.39) | FFAR3LCKFYNGLI1 | |
| Acetic Acid SCHEMBL2090071 | 0.94 | FFAR3 (0.39) | FFAR3LCKFYNGLI1 | |
| Acetic Acid SCHEMBL1528008 | 0.94 | FFAR3 (0.39) | FFAR3LCKFYNGLI1 | |
| Acetic Acid SCHEMBL1566799 | 0.94 | FFAR3 (0.39) | FFAR3LCKFYNGLI1 | |
| Acetic Acid SCHEMBL5711032 | 0.92 | FFAR3 (0.37) | FFAR3LCKFYN | |
| Acetic Acid SCHEMBL5554975 | 0.92 | FFAR3 (0.37) | FFAR3LCKFYN | |
| Glutarate SCHEMBL25307838 | 0.85 | SLC22A6 (0.44) | — | |
| Glutarate SCHEMBL25260627 | 0.80 | SLC22A6 (0.44) | — | |
| Butanedione SCHEMBL7163397 | 0.80 | TSHR (0.41) | GLI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805815-B1 | Use of bismuth compounds for the manufacture of medicaments for the treatment of gastric disorders caused by Helicobacter pylori | NYCOMED IMAGING AS (NO) | 2002-04-10 | — | — | EP | disclosed |
| US-6303101-B1 | TREATING A GASTROINTESTINAL DISORDER, ESPECIALLY AN ULCER CAUSED BY HELIOBACTER PYLORI. | NYCOMED IMAGING AS (NO) | 2001-10-16 | — | — | US | disclosed |
| US-6117412-A | ADMINISTERING BISMUTH COMPOUND CONTAINING ADDITIONAL HEAVY ATOM AS CONTRAST ENHANCER; X-RAYS, MAGNETIC RESONANCE, ULTRASOUND, AND SCINTIGRAPHIC IMAGING | NYCOMED IMAGING AS (NO) | 2000-09-12 | — | — | US | disclosed |
| US-5932190-A | Multinuclear complexes for X-ray imaging | NYCOMED SALUTAR, INC. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5817289-A | Non-cluster type bismuth compounds | NYCOMED IMAGING AS (NO) | 1998-10-06 | — | — | US | disclosed |
| EP-0805815-A1 | BISMUTH COMPOUNDS | NYCOMED IMAGING A/S (NO) | 1997-11-12 | — | — | EP | disclosed |
| US-5614168-A | Multinuclear complexes for X-ray imaging | NYCOMED SALUTAR INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996022994-A1 | BISMUTH COMPOUNDS | NYCOMED IMAGING A/S (NO) | 1996-08-01 | — | — | WO | disclosed |
| US-5482699-A | Multinuclear complexes for x-ray imaging | NYCOMED SALUTAR INC. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5458869-A | Used as contrast enhancing agents for medical diagnosis; tungsten complex | NYCOMED SALUTAR INC. (US) | 1995-10-17 | — | — | US | disclosed |
| EP-0645146-A1 | Contrast media | NYCOMED IMAGING AS (NO) | 1995-03-29 | — | — | EP | disclosed |
| EP-0577675-A1 | CONTRAST MEDIA | NYCOMED SALUTAR, INC. (US) | 1994-01-12 | — | — | EP | disclosed |
| EP-0521977-A1 | CONTRAST MEDIA. | NYCOMED IMAGING AS (NO) | 1993-01-13 | — | — | EP | disclosed |
| WO-1992017215-A1 | CONTRAST MEDIA | NYCOMED SALUTAR, INC. (US) | 1992-10-15 | — | — | WO | disclosed |
| WO-1991014460-A1 | CONTRAST MEDIA | COCKBAIN, JULIAN, RODERICK, MICHAELSON (GB) | 1991-10-03 | — | — | WO | disclosed |