SCHEMBL7532545

SCHEMBL7532545

CC(=O)Oc1cnc(N)c(C#N)n1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CUL4A Q13619 1/20 0.37
KDM4E B2RXH2 5/20 0.34
HSD17B10 Q99714 1/20 0.34
ALOX5AP P20292 3/20 0.34
FEN1 P39748 3/20 0.34
HTT P42858 1/20 0.33
ALDH1A1 P00352 6/20 0.33
HPGD P15428 3/20 0.33
MAPT P10636 3/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
RXFP1 Q9HBX9 1/20 0.32
PIK3CD O00329 1/20 0.32
PIK3R1 P27986 1/20 0.32
KMT2A Q03164 1/20 0.32
CTSL P07711 1/20 0.32
CTSB P07858 1/20 0.32
MAPK8 P45983 3/20 0.32
MAPK9 P45984 3/20 0.32
LMNA P02545 2/20 0.32
PRKD3 O94806 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4697306 0.76 KDM4E (0.35) KDM4EHSD17B10ALOX5APFEN1HTT
SCHEMBL16847937 0.71 AR (0.36) CUL4AKDM4EHSD17B10HTTALDH1A1
SCHEMBL24659989 0.71 ALOX5AP (0.32) KDM4EHSD17B10ALOX5APFEN1ALDH1A1
SCHEMBL24659983 0.71 ALOX5AP (0.32) KDM4EHSD17B10ALOX5APFEN1ALDH1A1
SCHEMBL23028982 0.71 ALOX5AP (0.32) KDM4EALOX5APFEN1ALDH1A1MAPT
SCHEMBL24659984 0.71 ALOX5AP (0.32) KDM4EALOX5APFEN1ALDH1A1MAPT
SCHEMBL23028979 0.71 ALOX5AP (0.32) KDM4EALOX5APFEN1ALDH1A1MAPT
SCHEMBL28031716 0.70 CNR2 (0.37) KMT2AMAP4K4
SCHEMBL9195651 0.69 KDM4E (0.41) KDM4EHSD17B10ALOX5APFEN1HTT
SCHEMBL7781784 0.68 USP8 (0.40) ALOX5APFEN1HTTPIK3CDPIK3R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1194809-A1 ELECTRO-OPTICAL DEVICE AND VARIABLE TRANSPARENT ARTICLE WITH SUCH DEVICE PPG Industries Ohio, Inc. (US) 2002-04-10 EP disclosed
WO-2000077559-A1 ELECTRO-OPTICAL DEVICE AND VARIABLE TRANSPARENT ARTICLE WITH SUCH DEVICE PPG INDUSTRIES OHIO, INC. (US) 2000-12-21 WO disclosed
US-5626797-A Non linear optical material and method for orientation thereof CANON KABUSHIKI KAISHA (JP) 1997-05-06 US disclosed
EP-0295145-B1 Recording method and recording apparatus CANON KK (JP) 1996-04-10 EP disclosed
EP-0282978-B1 Surface acoustic wave convolver with dielectric film of high non-linear effect CANON KK (JP) 1993-12-01 EP disclosed
EP-0284229-B1 NONLINEAR OPTICAL MATERIAL AND METHOD FOR ORIENTATION THEREOF CANON KABUSHIKI KAISHA (JP) 1993-07-21 EP disclosed
US-5037582-A Nonlinear optical material and method for orientation thereof CANON KABUSHIKI KAISHA (JP) 1991-08-06 US disclosed
US-4946261-A Recording method and recording apparatus CANON KABUSHIKI KAISHA (JP) 1990-08-07 US disclosed
US-4882715-A Surface acoustic wave convolver with dielectric film of high non-linear effect CANON KABUSHIKI KAISHA (JP) 1989-11-21 US disclosed
EP-0295145-A2 Recording method and recording apparatus CANON KABUSHIKI KAISHA (JP) 1988-12-14 EP disclosed
EP-0284229-A1 Nonlinear optical material and method for orientation thereof CANON KABUSHIKI KAISHA (JP) 1988-09-28 EP disclosed
EP-0282978-A2 Surface acoustic wave convolver with dielectric film of high non-linear effect CANON KABUSHIKI KAISHA (JP) 1988-09-21 EP disclosed