Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 12/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.65 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527242 | 0.99 | ESR1 (0.66) | ESR1ESR2PGRCHRM2HTR1A | |
| SCHEMBL8966126 | 0.93 | ESR1 (0.66) | ESR1ESR2PGRCHRM2HTR1A | |
| SCHEMBL8965793 | 0.93 | ESR1 (0.68) | ESR1ESR2PGRCHRM2HTR1A | |
| SCHEMBL8966242 | 0.93 | ESR1 (0.68) | ESR1ESR2PGRCHRM2HTR1A | |
| SCHEMBL7528598 | 0.92 | ESR1 (0.67) | ESR1ESR2PGRCHRM2HTR1A | |
| SCHEMBL7525280 | 0.91 | ESR1 (0.69) | ESR1ESR2LTA4H | |
| SCHEMBL7530403 | 0.90 | ESR1 (0.61) | ESR1ESR2KCNH2HRH3LTA4H | |
| SCHEMBL7526114 | 0.89 | ESR1 (0.63) | ESR1ESR2KCNH2HRH3 | |
| SCHEMBL7525989 | 0.89 | ESR1 (0.78) | ESR1ESR2CHRM2ADRA2AADORA3 | |
| SCHEMBL7528822 | 0.88 | ESR1 (0.78) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |