Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5533897 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL1025533 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL21634363 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL3843952 | 0.97 | — | — | |
| SCHEMBL3879064 | 0.90 | — | — | |
| SCHEMBL2029681 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL15871737 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL20836564 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL5569558 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL28569684 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882716-B1 | PYRIDINECARBOXAMIDE DERIVATIVES | NISSHIN PHARMA INC (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6046201-A | Pyridinecarboxamide derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0882716-A1 | PYRIDINECARBOXAMIDE DERIVATIVES | Nisshin Flour Milling Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |