Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 9/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 4/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | PRKCB | P05771 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | PRKCH | P24723 | 1/20 | 0.55 |
| ▸ | PRKCI | P41743 | 1/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774110 | 0.87 | MAP3K8 (0.74) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL7534239 | 0.80 | EGFR (0.52) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4770213 | 0.79 | MAP3K8 (0.80) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4774425 | 0.79 | MAP3K8 (0.76) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4769843 | 0.78 | MAP3K8 (0.75) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4767241 | 0.78 | MAP3K8 (0.78) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4775923 | 0.78 | MAP3K8 (0.74) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4772625 | 0.77 | MAP3K8 (0.74) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4767321 | 0.77 | MAP3K8 (0.74) | MAP3K8MAPK13SRCMAPK12MAP2K1 | |
| SCHEMBL4776745 | 0.77 | MAP3K8 (0.76) | MAP3K8MAPK13SRCMAPK12MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020165229-A1 | Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases | AMERICAN CYANAMID COMPANY | 2002-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165229-A1 | Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases | ABL1, ROS1, ALK | MAP3K8 67/4885MAPK13 448/4885SRC 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.