Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KDM5C | P41229 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28237909 | 0.96 | KDM4E (0.50) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| Hydrogen Peroxide SCHEMBL1310659 | 0.92 | — | — | |
| SCHEMBL9419864 | 0.92 | — | — | |
| Acetic Acid SCHEMBL28823501 | 0.88 | FFAR3 (0.58) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| Water SCHEMBL31585955 | 0.88 | MGAM (0.50) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| Hydrochloric Acid SCHEMBL3418039 | 0.88 | MGAM (0.50) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| SCHEMBL2128645 | 0.88 | MGAM (0.56) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| SCHEMBL1608 | 0.88 | — | — | |
| SCHEMBL10389469 | 0.88 | MGAM (0.56) | KDM4EKDM5CEGLN1PHF8KDM2A | |
| Acetic Acid SCHEMBL28006968 | 0.85 | FFAR3 (0.54) | KDM4EKDM5CEGLN1PHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002014343-A1 | BUFADIENOLIDE DERIVATIVES AND USE AS IMMUNOSUPPRESSIVE, ANTIINFLAMMATORY AND ANALGESIC AGENTS | TERNESS, PETER (DE) | 2002-02-21 | — | — | WO | disclosed |