Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL10426239 | 0.88 | MEN1 (0.52) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL308308 | 0.85 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| SCHEMBL20522969 | 0.85 | — | — | |
| SCHEMBL11557802 | 0.85 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| SCHEMBL9400799 | 0.82 | MEN1 (0.75) | MEN1KMT2AKDM4EGAACYP2C9 | |
| SCHEMBL5314604 | 0.82 | MEN1 (0.75) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL1932496 | 0.82 | MEN1 (0.73) | MEN1KMT2AKDM4EGAACYP2C9 | |
| SCHEMBL9868765 | 0.81 | MEN1 (0.38) | MEN1KMT2AKDM4EGAACYP2C9 | |
| SCHEMBL23742743 | 0.79 | MEN1 (0.71) | MEN1KMT2AKDM4EGAACYP2C9 | |
| SCHEMBL9400796 | 0.79 | MEN1 (0.71) | MEN1KMT2AKDM4EGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |