SCHEMBL7534870

SCHEMBL7534870

Cc1cc(C)cc(N=C=O)c1.Cc1ccc(N=C=O)cc1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.59
TRPA1 O75762 1/20 0.59
TDP1 Q9NUW8 2/20 0.44
MAPK1 P28482 1/20 0.44
TSHR P16473 1/20 0.38
ALDH1A1 P00352 6/20 0.34
PMM2 O15305 1/20 0.33
MPI P34949 1/20 0.33
CYP1A2 P05177 1/20 0.33
MAPT P10636 4/20 0.32
RAB9A P51151 3/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
NPC1 O15118 2/20 0.32
LMNA P02545 1/20 0.32
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
USP2 O75604 1/20 0.31
HSD17B10 Q99714 1/20 0.31
HTT P42858 2/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL58809 0.90 CYP3A4 (0.70) CYP3A4TRPA1TDP1MAPK1TSHR
SCHEMBL59852 0.84 CYP3A4 (0.48) CYP3A4TRPA1TDP1MAPK1TSHR
Benzene SCHEMBL28982643 0.80 CYP3A4 (0.45) CYP3A4TRPA1TDP1MAPK1TSHR
SCHEMBL109084 0.80 CYP3A4 (0.48) CYP3A4TRPA1TDP1MAPK1TSHR
SCHEMBL7002811 0.78 CYP3A4 (0.44) CYP3A4TRPA1TDP1MAPK1TSHR
SCHEMBL667517 0.76 CYP3A4 (0.62) CYP3A4TRPA1TDP1MAPK1TSHR
SCHEMBL18568763 0.75 CYP3A4 (0.77) CYP3A4TRPA1TDP1MAPK1TSHR
Toluene Diisocyanate SCHEMBL29737260 0.75 CYP3A4 (1.00) CYP3A4TRPA1TDP1MAPK1TSHR
SCHEMBL29373346 0.75 CYP3A4 (0.71) CYP3A4TRPA1TDP1MAPK1TSHR
Toluene Diisocyanate SCHEMBL29350148 0.75 CYP3A4 (1.00) CYP3A4TRPA1TDP1MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP disclosed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO disclosed