Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534575 | 1.00 | SLC6A2 (0.42) | SLC6A2SLC6A3SLC6A4HRH3HTR2A | |
| SCHEMBL7534567 | 1.00 | SLC6A2 (0.42) | SLC6A2SLC6A3SLC6A4HRH3HTR2A | |
| SCHEMBL7533530 | 0.85 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4HRH3HTR2A | |
| SCHEMBL7533925 | 0.85 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4HRH3HTR2A | |
| SCHEMBL7533532 | 0.85 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4HRH3HTR2A | |
| SCHEMBL26619764 | 0.72 | SLC6A2 (0.54) | SLC6A2SLC6A3SLC6A4HRH3PDE9A | |
| SCHEMBL1429949 | 0.70 | AXL (0.57) | HRH3 | |
| SCHEMBL7531341 | 0.69 | SLC6A4 (0.56) | SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL7531345 | 0.69 | SLC6A4 (0.56) | SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL7588873 | 0.69 | SLC6A4 (0.56) | SLC6A2SLC6A3SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228065-A1 | (INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Wyeth (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6245799-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORP | 2001-06-12 | — | — | US | disclosed |
| WO-2001034598-A1 | [(INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WYETH (US) | 2001-05-17 | — | — | WO | disclosed |