SCHEMBL7535839

SCHEMBL7535839

O=C(NO)c1ccc2ocnc2c1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 2/20 0.59
CTNNB1 P35222 4/20 0.56
WNT3A P56704 4/20 0.56
HDAC6 Q9UBN7 10/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
GAA P10253 1/20 0.50
KMT2A Q03164 1/20 0.50
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
TAS1R3 Q7RTX0 1/20 0.47
TAS1R1 Q7RTX1 1/20 0.47
FOXO1 Q12778 1/20 0.46
HDAC3 O15379 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC8 Q9BY41 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL19029201 0.90 CTNNB1 (0.51) NAMPTCTNNB1WNT3AHDAC6MEN1
SCHEMBL15157952 0.85 NAMPT (0.58) NAMPTCTNNB1WNT3AHDAC6MEN1
SCHEMBL703854 0.81 CTNNB1 (0.65) NAMPTCTNNB1WNT3AMEN1ALDH1A1
SCHEMBL31473769 0.80 TDP1 (0.55) NAMPTCTNNB1WNT3AMEN1ALDH1A1
SCHEMBL2004863 0.79 CTNNB1 (0.59) NAMPTCTNNB1WNT3AMEN1ALDH1A1
SCHEMBL2004862 0.79 CTNNB1 (0.59) NAMPTCTNNB1WNT3AMEN1ALDH1A1
SCHEMBL4643431 0.79 CTNNB1 (0.59) NAMPTCTNNB1WNT3AMEN1ALDH1A1
SCHEMBL29431267 0.79 CTNNB1 (0.55) NAMPTCTNNB1WNT3AMEN1ALDH1A1
SCHEMBL6761565 0.79 CTNNB1 (0.55) NAMPTCTNNB1WNT3AMEN1ALDH1A1
Hydrochloric Acid SCHEMBL27775517 0.78 CTNNB1 (0.57) NAMPTCTNNB1WNT3AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202731-A2 METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-05-08 EP disclosed
EP-1144385-A1 BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-10-17 EP disclosed
WO-2001005390-A2 METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-01-25 WO disclosed
WO-2000042022-A1 BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 2000-07-20 WO disclosed