Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terbogrel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R known ✓ | P21731 | 20/20 | 0.75 |
| ▸ | TBXAS1 known ✓ | P24557 | 20/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terbogrel SCHEMBL13030802 | 1.00 | TBXA2R (0.75) | TBXA2RTBXAS1 | |
| Terbogrel SCHEMBL29383187 | 1.00 | TBXA2R (0.75) | TBXA2RTBXAS1 | |
| Terbogrel SCHEMBL7537043 | 1.00 | TBXA2R (0.75) | TBXA2RTBXAS1 | |
| Terbogrel SCHEMBL7537036 | 1.00 | TBXA2R (0.75) | TBXA2RTBXAS1 | |
| SCHEMBL9002323 | 0.97 | TBXA2R (0.74) | TBXA2RTBXAS1 | |
| SCHEMBL9002730 | 0.97 | TBXA2R (0.75) | TBXA2RTBXAS1 | |
| SCHEMBL9002333 | 0.94 | TBXA2R (0.73) | TBXA2RTBXAS1 | |
| SCHEMBL9002313 | 0.94 | TBXA2R (0.73) | TBXA2RTBXAS1 | |
| SCHEMBL9002321 | 0.94 | TBXA2R (0.73) | TBXA2RTBXAS1 | |
| SCHEMBL9002464 | 0.94 | TBXA2R (0.72) | TBXA2RTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1190714-A2 | Method for the treatment of thromboembolic disorders in patients with aspirin resistance | Schrör, Karsten, Prof. Dr. (DE) | 2002-03-27 | — | — | EP | claimed |
| EP-1190714-A3 | Method for the treatment of thromboembolic disorders in patients with aspirin resistance | Schrör, Karsten, Prof. Dr. (DE) | 2002-04-03 | — | — | EP | disclosed |
| EP-1190714-A2 | Method for the treatment of thromboembolic disorders in patients with aspirin resistance | Schrör, Karsten, Prof. Dr. (DE) | 2002-03-27 | — | — | EP | disclosed |
| EP-1190714-A2 | Method for the treatment of thromboembolic disorders in patients with aspirin resistance | Schrör, Karsten, Prof. Dr. (DE) | 2002-03-27 | — | — | EP | disclosed |