Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537404 | 1.00 | NPC1 (0.53) | NPC1KDM4EALDH1A1TP53HPGD | |
| Hydrochloric Acid SCHEMBL7539747 | 0.99 | NPC1 (0.52) | NPC1KDM4EALDH1A1TP53HPGD | |
| Hydrochloric Acid SCHEMBL7539746 | 0.99 | NPC1 (0.52) | NPC1KDM4EALDH1A1TP53HPGD | |
| SCHEMBL7537821 | 0.99 | NPC1 (0.54) | NPC1KDM4EALDH1A1TP53HPGD | |
| SCHEMBL7537586 | 0.99 | NPC1 (0.54) | NPC1KDM4EALDH1A1TP53HPGD | |
| SCHEMBL2121847 | 0.99 | NPC1 (0.54) | NPC1KDM4EALDH1A1TP53HPGD | |
| Hydrochloric Acid SCHEMBL7540959 | 0.98 | NPC1 (0.53) | NPC1KDM4EALDH1A1TP53HPGD | |
| Hydrochloric Acid SCHEMBL7540963 | 0.98 | NPC1 (0.53) | NPC1KDM4EALDH1A1TP53HPGD | |
| SCHEMBL7538868 | 0.97 | NPC1 (0.54) | NPC1KDM4EALDH1A1TP53HPGD | |
| SCHEMBL7538873 | 0.97 | NPC1 (0.54) | NPC1KDM4EALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676960-B1 | CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | AVENTIS PHARM PROD INC (US) | 2002-05-22 | — | — | EP | claimed |
| US-5451596-A | Cycloalkyl amine bis-aryl squalene synthase inhibitors | RHONE POULENC RORER PHARMACEUTICALS INC. (US) | 1995-09-19 | — | — | US | claimed |