SCHEMBL7538352

SCHEMBL7538352

COc1ccc2ccc(S(=O)(=O)NC3CCN(CC(=O)Nc4ccncc4)C3=O)cc2c1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 16/20 0.59
KLK6 Q92876 1/20 0.59
F2 P00734 6/20 0.59
PLG P00747 2/20 0.56
PROC P04070 2/20 0.56
PRSS1 P07477 2/20 0.56
PLAT P00750 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7214106 0.87 F10 (0.58) F10KLK6F2PLGPROC
SCHEMBL7214103 0.87 F10 (0.58) F10KLK6F2PLGPROC
SCHEMBL7220106 0.85 F10 (0.67) F10KLK6F2PLGPROC
SCHEMBL7220112 0.85 F10 (0.67) F10KLK6F2PLGPROC
SCHEMBL14603144 0.78 F10 (0.79) F10KLK6
SCHEMBL7564200 0.77 F10 (0.62) F10KLK6F2PLGPROC
Trifluoroacetic Acid SCHEMBL7371957 0.75 F10 (0.58) F10KLK6F2PLGPROC
SCHEMBL7545956 0.75 F10 (0.83) F10F2PLGPROCPRSS1
SCHEMBL7376474 0.74 F10 (0.71) F10KLK6F2PLGPROC
SCHEMBL2326339 0.74 F10 (0.74) F10F2PLGPROCPRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMACEUTICALS PRODUCTS INC. 2002-01-31 US claimed
US-6281227-B1 INHIBITORS OF THE ACTIVITY OF FACTOR XA. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-08-28 US claimed
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMACEUTICALS PRODUCTS INC. 2002-01-31 US disclosed
US-6281227-B1 INHIBITORS OF THE ACTIVITY OF FACTOR XA. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-08-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds STS, ARSA, F12 F10 20/4885KLK6 954/4885F2 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.