Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 6/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429364 | 0.93 | KMT2A (0.41) | LMNAKMT2AMEN1MAPTRECQL | |
| SCHEMBL7424191 | 0.83 | KMT2A (0.41) | LMNAKMT2AMEN1MAPTPDE4B | |
| SCHEMBL6585029 | 0.82 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6582645 | 0.81 | HMGCR (0.46) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6587471 | 0.79 | POLB (0.48) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6586047 | 0.78 | PDE4B (0.41) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6586152 | 0.77 | PDE4A (0.42) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL15265616 | 0.74 | PDE5A (0.46) | LMNAKMT2AMEN1MAPTRECQL | |
| SCHEMBL6586929 | 0.73 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7324666 | 0.71 | RECQL (0.58) | RECQLPDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042300-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032456-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |