Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.79 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662589 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7532671 | 0.89 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7421512 | 0.86 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8179807 | 0.85 | KMT2A (1.00) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8168741 | 0.85 | KDM4E (0.82) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL6664629 | 0.82 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| Hydrochloric Acid SCHEMBL6660919 | 0.81 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7420809 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7415138 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL6659507 | 0.79 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821366-A | Xanthines and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-10-13 | — | — | US | claimed |
| EP-0825993-A1 | XANTHINES AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036638-A1 | XANTHINES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |