Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | TDO2 | P48775 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5546047 | 0.77 | IDO1 (0.50) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL4668171 | 0.72 | IDO1 (0.61) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL5537747 | 0.71 | IDO1 (0.58) | IDO1TDO2TSHRHIF1ALMNA | |
| SCHEMBL17616547 | 0.69 | ACP3 (0.49) | TDP1NR3C1PGRMAPTCNR1 | |
| SCHEMBL3719325 | 0.69 | TSHR (0.44) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL791590 | 0.69 | IDO1 (0.56) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL28704077 | 0.68 | IDO1 (0.40) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL4667552 | 0.67 | IDO1 (0.54) | IDO1TDO2TSHRHIF1ALMNA | |
| SCHEMBL1920526 | 0.65 | TSHR (0.41) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL9294071 | 0.65 | TSHR (0.41) | IDO1TDO2TSHRHIF1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | claimed |