Lactisole

Lactisole

SCHEMBL7540880

COc1ccc(OC(C)C(=O)O)cc1.[NaH]

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.65
CYP1A2 P05177 1/20 0.65
CYP2C9 P11712 1/20 0.65
PKM P14618 1/20 0.65
CYP2C19 P33261 1/20 0.65
TAS1R3 Q7RTX0 1/20 0.65
TAS1R1 Q7RTX1 1/20 0.65
TAS1R2 Q8TE23 1/20 0.65
TDP1 Q9NUW8 1/20 0.59
KMT2A Q03164 1/20 0.55
ALDH1A1 P00352 2/20 0.52
HPGD P15428 2/20 0.52
KDM4E B2RXH2 1/20 0.52
RECQL P46063 1/20 0.52
RXFP1 Q9HBX9 1/20 0.52
LDHA P00338 1/20 0.52
PPARG P37231 3/20 0.51
PPARA Q07869 3/20 0.51
POLB P06746 1/20 0.51
APOBEC3A P31941 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lactisole SCHEMBL5600662 0.98 GAA (0.67) GAACYP1A2CYP2C9PKMCYP2C19
Lactisole SCHEMBL10667608 0.98 GAA (0.67) GAACYP1A2CYP2C9PKMCYP2C19
Lactisole SCHEMBL352607 0.98 GAA (0.67) GAACYP1A2CYP2C9PKMCYP2C19
Lactisole SCHEMBL28635716 0.96 GAA (0.65) GAACYP1A2CYP2C9PKMCYP2C19
Lactisole SCHEMBL27890219 0.96 GAA (0.65) GAACYP1A2CYP2C9PKMCYP2C19
SCHEMBL4262556 0.89 CYP1A2 (0.77) GAACYP1A2CYP2C9PKMCYP2C19
SCHEMBL10706539 0.84 CYP1A2 (0.65) GAACYP1A2CYP2C9PKMCYP2C19
SCHEMBL28971374 0.84 CYP1A2 (0.65) GAACYP1A2CYP2C9PKMCYP2C19
SCHEMBL28971376 0.84 CYP1A2 (0.65) GAACYP1A2CYP2C9PKMCYP2C19
SCHEMBL11550164 0.83 CYP1A2 (0.69) GAACYP1A2CYP2C9PKMCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107581655-B Compound sweet-taste-free electronic cigarette tobacco tar and preparation method thereof 深圳市真味生物科技有限公司 2020-10-02 CN claimed
CN-105767148-B The application of 2- (4- methoxyphenoxy) propionic acid and its citrus postharvest storage antisepsis antistaling agent 华中农业大学 2019-08-27 CN claimed
CN-105767148-A Application of 2-(4-methoxyphenoxy) propionic acid and antiseptic preservative agent for preservation of citrus after harvest 华中农业大学 2016-07-20 CN claimed
WO-1994026122-A1 LACTOSE-HYDROLYZED MILK AND MILK PRODUCTS WITH IMPROVED TASTE AND SUPPRESSED SWEETNESS STERLING WINTHROP INC. (US) 1994-11-24 WO claimed
EP-0558141-A1 Lactose-hydrolyzed milk with suppressed sweetness STERLING WINTHROP INC. (US) 1993-09-01 EP claimed
CN-107581655-B Compound sweet-taste-free electronic cigarette tobacco tar and preparation method thereof 深圳市真味生物科技有限公司 2020-10-02 CN disclosed
CN-103284986-B 2-(4-methoxyphenoxy) propionic acid and application of metal salt thereof in preparation of medicament for lowering blood fat UNIV HUAZHONG AGRICULTURAL 2015-04-08 CN disclosed
US-20020188019-A1 Use of hydroxyflavanones for masking bitter taste SYMRISE AG (DE) 2002-12-12 US disclosed
US-6015792-A Specific eatable taste modifiers BIORESEARCH, INC. (US) 2000-01-18 US disclosed
US-6008250-A Specific eatable taste modifiers BIORESEARCH, INC. (US) 1999-12-28 US disclosed
US-5866608-A AROMATIC COMPOUNDS BIORESEARCH, INC. (US) 1999-02-02 US disclosed
US-5703053-A TASTELESS INGESTIBLE COMPOUNDS WHICH REDUCE OR ELIMINATE UNDESIRABLE TASTES IN EATABLES BIORESEARCH, INC. (US) 1997-12-30 US disclosed
EP-0727149-A2 Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers BIORESEARCH, INC. (US) 1996-08-21 EP disclosed
EP-0661932-A4 SPECIFIC EATABLE TASTE MODIFIERS. BIORESEARCH INC (US) 1996-06-05 EP disclosed
EP-0661932-A1 SPECIFIC EATABLE TASTE MODIFIERS BIORESEARCH, INC. (US) 1995-07-12 EP disclosed
US-5232735-A INGESTIBLES CONTAINING SUBSTANTIALLY TASTELESS SWEETNESS INHIBITORS AS BITTER TASTE REDUCERS OR SUBSTANTIALLY TASTELESS BITTER INHIBITORS AS SWEET TASTE REDUCERS BIORESEARCH, INC. (US) 1993-08-03 US disclosed
WO-1993010677-A1 SPECIFIC EATABLE TASTE MODIFIERS BIORESEARCH, INC. (US) 1993-06-10 WO disclosed
EP-0485587-A4 INGESTIBLES CONTAINING SUBSTANTIALLY TASTELESS SWEETNESS INHIBITORS AS BITTER TASTE REDUCERS OR SUBSTANTIALLY TASTELESS BITTER INHIBITORS AS SWEET TASTE REDUCERS 1992-12-02 EP disclosed
EP-0485587-A1 INGESTIBLES CONTAINING SUBSTANTIALLY TASTELESS SWEETNESS INHIBITORS AS BITTER TASTE REDUCERS OR SUBSTANTIALLY TASTELESS BITTER INHIBITORS AS SWEET TASTE REDUCERS. BIORESEARCH INC (US) 1992-05-20 EP disclosed
WO-1991018523-A1 INGESTIBLES CONTAINING SUBSTANTIALLY TASTELESS SWEETNESS INHIBITORS AS BITTER TASTE REDUCERS OR SUBSTANTIALLY TASTELESS BITTER INHIBITORS AS SWEET TASTE REDUCERS BIORESEARCH, INC. (US) 1991-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020188019-A1 Use of hydroxyflavanones for masking bitter taste TAS2R60, TAS2R50, TAS2R30 GAA 1156/4885CYP1A2 630/4885CYP2C9 1565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.