Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846576 | 0.91 | MAP3K20 (0.43) | MAP3K20RAF1BRAFTAAR1NTRK1 | |
| SCHEMBL6845411 | 0.89 | TAAR1 (0.49) | MAP3K20RAF1BRAFTAAR1NTRK1 | |
| SCHEMBL6846581 | 0.82 | SCN9A (0.41) | MAP3K20HPGDMAPK14ABL1 | |
| SCHEMBL6841239 | 0.80 | MAP3K20 (0.43) | MAP3K20RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL6846667 | 0.79 | HPGD (0.43) | MAP3K20RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL6846684 | 0.76 | TP53 (0.48) | RAF1BRAFTAAR1NTRK1DDR1 | |
| SCHEMBL7015526 | 0.74 | TAAR1 (0.45) | MAP3K20RAF1BRAFTAAR1NTRK1 | |
| SCHEMBL6846899 | 0.73 | HPGD (0.44) | MAPTSMN1; SMN2HPGDMAPK14 | |
| SCHEMBL6846845 | 0.73 | HPGD (0.44) | BRAFMAPTSMN1; SMN2HPGD | |
| SCHEMBL6841384 | 0.69 | ABL1 (0.41) | BRAFDDR1TP53MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252146-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001053274-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | disclosed |