Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820566 | 0.91 | NTRK1 (0.49) | NTRK1RAB9ALMNANPC1HTT | |
| SCHEMBL3089387 | 0.89 | NTRK1 (0.59) | NTRK1RAB9ALMNANPC1MAPK1 | |
| SCHEMBL7831508 | 0.88 | HAO1 (0.40) | NTRK1HAO1RAB9ALMNANPC1 | |
| SCHEMBL3089833 | 0.88 | NTRK1 (0.58) | NTRK1HAO1RAB9ALMNANPC1 | |
| SCHEMBL7830387 | 0.87 | HAO1 (0.41) | NTRK1HAO1RAB9ALMNANPC1 | |
| SCHEMBL7831837 | 0.85 | KDR (0.44) | NTRK1HAO1RAB9ALMNANPC1 | |
| SCHEMBL7827786 | 0.85 | HAO1 (0.40) | NTRK1HAO1RAB9ALMNANPC1 | |
| SCHEMBL7828201 | 0.84 | KDR (0.43) | HAO1RAB9ALMNANPC1MAPK1 | |
| SCHEMBL7829778 | 0.84 | KDR (0.41) | HAO1RAB9ALMNANPC1MAPK1 | |
| SCHEMBL7819682 | 0.83 | KDR (0.41) | HAO1RAB9ALMNANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | claimed |
| EP-1187826-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000071532-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | claimed |
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1187826-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000071532-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | disclosed |