⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27991687 | 0.97 | — | — | |
| SCHEMBL11882336 | 0.90 | EPHX1 (0.42) | — | |
| SCHEMBL28147635 | 0.90 | — | — | |
| SCHEMBL22534832 | 0.88 | EPHX1 (0.45) | — | |
| SCHEMBL22627429 | 0.88 | EPHX1 (0.45) | — | |
| SCHEMBL28815393 | 0.88 | EPHX1 (0.36) | — | |
| SCHEMBL1427273 | 0.88 | EPHX1 (0.45) | — | |
| SCHEMBL27991856 | 0.86 | EPHX1 (0.44) | — | |
| SCHEMBL3304240 | 0.84 | PIK3CD (0.37) | — | |
| SCHEMBL27957243 | 0.84 | EPHX1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115385810-A | Preparation method of N-cyclopropyl-glycine | 宁夏太康药业有限公司 | 2022-11-25 | — | — | CN | claimed |
| CN-103922952-A | Method for preparing cyclopropylglycine by using hydroxyacetonitrile | NINGXIA BAOMA PHARMACEUTICAL CO LTD | 2014-07-16 | — | — | CN | claimed |
| CN-110105434-A | The polypeptide and application thereof of stitching and suture | 哈佛大学的校长及成员们 | 2019-08-09 | — | — | CN | disclosed |
| CN-105307667-B | Stapled and sutured polypeptides and uses thereof | 哈佛大学的校长及成员们 | 2019-04-19 | — | — | CN | disclosed |
| CN-105753965-A | Conjugate Based Systems For Controlled Drug Delivery | 斯马特塞尔斯公司 | 2016-07-13 | — | — | CN | disclosed |
| WO-2016106625-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | disclosed |
| CN-105307667-A | Stapled and sutured polypeptides and uses thereof | HARVARD COLLEGE | 2016-02-03 | — | — | CN | disclosed |
| CN-103922952-A | Method for preparing cyclopropylglycine by using hydroxyacetonitrile | NINGXIA BAOMA PHARMACEUTICAL CO LTD | 2014-07-16 | — | — | CN | disclosed |
| CN-101553474-B | Imidazolidinone and imidazolidinone derivatives as 11b-HSD1 inhibitors for diabetes | HOFFMANN LA ROCHE | 2013-02-27 | — | — | CN | disclosed |
| US-8129423-B2 | 1-Adamantan-2-yl-3-benzyl-1,3-dihydro-imidazol-2-one; 11beta-hydroxysteroid dehydrogenases (11beta-HSD) inhibitor; antidiabetic, hypotensive, hypoglycemic agent; resist hyperglycemia provoked by obesity or stress; | HOFFMAN-LA ROCHE INC. (US) | 2012-03-06 | — | — | US | disclosed |
| CN-102365025-A | Conjugate-based systems for controlled drug delivery | SMARTCELLS INC | 2012-02-29 | — | — | CN | disclosed |
| EP-2308851-A1 | Imidazolone and imidazolidinone derivatives as 11B-HSD1 inhibitors for the treatment of diabetes | F. Hoffmann-La Roche AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| US-20080103183-A1 | NEW IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2008-05-01 | — | — | US | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |
| US-7241893-B2 | Thiazolinone 2-substituted quinolines | HOFFMAN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-4156002-A | ANTIINFLAMMAOTRY AGENTS, ANALGESICS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-05-22 | — | — | US | disclosed |