Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7639665 | 1.00 | KMT2A (0.42) | KMT2AMEN1APPPKMCNR1 | |
| SCHEMBL7642333 | 1.00 | KMT2A (0.42) | KMT2AMEN1APPPKMCNR1 | |
| SCHEMBL7639660 | 1.00 | KMT2A (0.42) | KMT2AMEN1APPPKMCNR1 | |
| SCHEMBL7546331 | 0.92 | KMT2A (0.43) | KMT2AMEN1CNR1CNR2ABCG2 | |
| SCHEMBL7546336 | 0.92 | KMT2A (0.43) | KMT2AMEN1CNR1CNR2ABCG2 | |
| SCHEMBL7550960 | 0.92 | KMT2A (0.44) | KMT2AMEN1APPABCG2CYP1A2 | |
| SCHEMBL7550962 | 0.92 | KMT2A (0.44) | KMT2AMEN1APPABCG2CYP1A2 | |
| SCHEMBL7639653 | 0.89 | KMT2A (0.46) | KMT2AMEN1ABCG2CYP1A2CYP3A4 | |
| SCHEMBL7550660 | 0.89 | KMT2A (0.46) | KMT2AMEN1ABCG2CYP1A2CYP3A4 | |
| SCHEMBL7550661 | 0.89 | KMT2A (0.46) | KMT2AMEN1ABCG2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462046-B2 | NON-THIAZOLIDINEDIONE PPARGAMMA AGONISTS; USEFUL IN MODULATION OF BLOOD GLUCOSE AND THE INCREASE OF INSULIN SENSITIVITY IN MAMMALS | ADVANCED SYNTECH, LLC | 2002-10-08 | — | — | US | claimed |
| US-20020082263-A1 | Heterocycle derivatives as PPAR-gamma agonists | ADVANCED SYNTECH LLC | 2002-06-27 | — | — | US | claimed |
| US-6462046-B2 | NON-THIAZOLIDINEDIONE PPARGAMMA AGONISTS; USEFUL IN MODULATION OF BLOOD GLUCOSE AND THE INCREASE OF INSULIN SENSITIVITY IN MAMMALS | ADVANCED SYNTECH, LLC | 2002-10-08 | — | — | US | disclosed |
| WO-2002053546-A1 | HETEROCYCLE DERIVATIVES AS PPAR-GAMMA AGONISTS | ADVANCED SYNTECH, LLC (US) | 2002-07-11 | — | — | WO | disclosed |
| US-20020082263-A1 | Heterocycle derivatives as PPAR-gamma agonists | ADVANCED SYNTECH LLC | 2002-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082263-A1 | Heterocycle derivatives as PPAR-gamma agonists | PPARG, PPARD, PPARA | KMT2A 2543/4885MEN1 4629/4885APP 2758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.