Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.49 |
| ▸ | EED | O75530 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383375 | 0.93 | GBA1 (0.56) | GBA1SLC6A4ATMSLC6A2HRH3 | |
| Fumaric Acid SCHEMBL7491467 | 0.88 | HRH1 (0.46) | GBA1SLC6A4SLC6A2 | |
| Fumaric Acid SCHEMBL7491458 | 0.88 | HRH1 (0.46) | GBA1SLC6A4SLC6A2 | |
| SCHEMBL11633199 | 0.87 | EED (0.56) | EEDATMSLC6A2HRH3HRH4 | |
| SCHEMBL16334148 | 0.84 | ATM (0.50) | SLC6A4ATM | |
| SCHEMBL16334656 | 0.84 | ATM (0.50) | SLC6A4ATM | |
| SCHEMBL7489765 | 0.83 | HRH4 (0.45) | GBA1SLC6A4EEDATMSLC6A2 | |
| SCHEMBL29889431 | 0.83 | HRH4 (0.45) | GBA1SLC6A4EEDATMSLC6A2 | |
| SCHEMBL15667971 | 0.83 | HRH4 (0.45) | GBA1SLC6A4EEDATMSLC6A2 | |
| Fumaric Acid SCHEMBL6388246 | 0.81 | HRH1 (0.49) | GBA1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146871-A4 | ANTIDEPRESSANT HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1146871-A1 | ANTIDEPRESSANT HETEROCYCLIC COMPOUNDS | Bristol-Myers Squibb Company (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6225324-B1 | POTENT INHIBITION OF 5-HT REUPTAKE; 1,3-DISUBSTITUTED PYRROLIDINE, 1,4-DISUBSTITUTED PIPERIDINE, OR 1,4-DISUBSTITUTED HEXAHYDROAZEPINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2001-05-01 | — | — | US | disclosed |
| WO-2000044376-A1 | ANTIDEPRESSANT HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |