Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.47 |
| ▸ | IKBKB | O14920 | 4/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999161 | 0.86 | CHEK1 (0.51) | CHEK1IKBKBSGK1CHEK2PRKCG | |
| SCHEMBL6999164 | 0.86 | CHEK1 (0.51) | CHEK1IKBKBSGK1CHEK2PRKCG | |
| Hydrochloric Acid SCHEMBL7003730 | 0.85 | CHEK1 (0.50) | CHEK1IKBKBSGK1CHEK2PRKCG | |
| Hydrochloric Acid SCHEMBL7003736 | 0.85 | CHEK1 (0.50) | CHEK1IKBKBSGK1CHEK2PRKCG | |
| SCHEMBL7002731 | 0.83 | CHEK1 (0.58) | CHEK1KDRMAPTCDK2 | |
| SCHEMBL7095886 | 0.74 | CHEK1 (0.57) | CHEK1SGK1CHEK2PRKCGAKT1 | |
| SCHEMBL13611546 | 0.74 | HPGD (0.60) | IKBKBMAPT | |
| SCHEMBL6999095 | 0.74 | CHEK1 (0.54) | CHEK1SGK1CHEK2PRKCGAKT1 | |
| SCHEMBL7000847 | 0.73 | CHEK1 (0.60) | CHEK1SGK1CHEK2PRKCGAKT1 | |
| SCHEMBL7089915 | 0.71 | CHEK1 (0.68) | CHEK1SGK1CHEK2PRKCGAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165544-A1 | SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059901-A1 | SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE | KNOLL GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2000-10-12 | — | — | WO | disclosed |