Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | QPCT | Q16769 | 2/20 | 0.42 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551275 | 0.93 | KDR (0.47) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7550186 | 0.93 | KDR (0.49) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7554304 | 0.93 | KDR (0.54) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7551283 | 0.92 | KDR (0.49) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7994209 | 0.88 | KDR (0.46) | KDRFLT1FLT4SMYD2MAPT | |
| SCHEMBL7547530 | 0.88 | KDR (0.49) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7553945 | 0.88 | KDR (0.66) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7976639 | 0.88 | FLT1 (0.47) | KDRFLT1FLT4GSK3BKDM5B | |
| SCHEMBL7549814 | 0.86 | FLT1 (0.47) | KDRFLT1FLT4SMYD2ALDH1A1 | |
| SCHEMBL7549576 | 0.86 | KDR (0.51) | KDRFLT1FLT4GSK3BQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |