Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020303 | 1.00 | LCK (0.64) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7014887 | 0.94 | LCK (0.69) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7022474 | 0.92 | LCK (0.73) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7593900 | 0.92 | LCK (0.73) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7023569 | 0.92 | LCK (0.62) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7022787 | 0.91 | LCK (0.70) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7021493 | 0.90 | LCK (0.62) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7022463 | 0.90 | LCK (0.62) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7599669 | 0.90 | LCK (0.62) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7586853 | 0.89 | LCK (0.67) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |