Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.53 |
| ▸ | MTOR | P42345 | 15/20 | 0.53 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773798 | 0.89 | PIK3CA (0.61) | PIK3CAMTORPDE4BPDE4APDE4C | |
| SCHEMBL2771543 | 0.87 | PIK3CA (0.69) | PIK3CAMTORPDE4BPDE4APDE4C | |
| SCHEMBL754608 | 0.84 | PIK3CA (0.55) | PIK3CAMTORPDE4BPDE4APDE4C | |
| SCHEMBL756343 | 0.84 | PIK3CA (0.60) | PIK3CAMTOR | |
| SCHEMBL2776327 | 0.83 | PIK3CA (0.71) | PIK3CAMTOR | |
| SCHEMBL750520 | 0.83 | PIK3CA (0.67) | PIK3CAMTOR | |
| SCHEMBL755161 | 0.83 | MTOR (0.71) | PIK3CAMTORPDE4BPDE4D | |
| SCHEMBL2772495 | 0.83 | PIK3CA (0.57) | PIK3CAMTOR | |
| SCHEMBL2787760 | 0.83 | PIK3CA (0.54) | PIK3CAMTORPDE4BPDE4APDE4C | |
| SCHEMBL2772795 | 0.82 | PIK3CA (0.72) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | claimed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |