Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 8/20 | 0.67 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755391 | 0.87 | NR3C2 (0.72) | NR3C2BRD4PGRMEN1KMT2A | |
| SCHEMBL755900 | 0.86 | NR3C2 (0.71) | NR3C2BRD4PGR | |
| SCHEMBL757508 | 0.85 | NR3C2 (0.70) | NR3C2BRD4PGRMEN1KMT2A | |
| SCHEMBL756074 | 0.85 | NR3C2 (0.70) | NR3C2BRD4PGRMEN1KMT2A | |
| SCHEMBL755769 | 0.85 | NR3C2 (0.64) | NR3C2SCN9ABRD4NR3C1PGR | |
| SCHEMBL754316 | 0.84 | NR3C2 (0.69) | NR3C2BRD4PGR | |
| SCHEMBL753401 | 0.83 | NR3C2 (0.66) | NR3C2BRD4PGRMEN1KMT2A | |
| SCHEMBL753323 | 0.83 | NR3C2 (0.66) | NR3C2BRD4 | |
| SCHEMBL755242 | 0.82 | NR3C2 (0.65) | NR3C2BRD4NR3C1PGR | |
| SCHEMBL753819 | 0.81 | NR3C2 (0.64) | NR3C2BRD4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | disclosed |