Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.47 |
| ▸ | MTOR | P42345 | 10/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753575 | 0.86 | PIK3CA (0.62) | PIK3CAMTORPDE4BPDE4DPDE4A | |
| SCHEMBL750996 | 0.76 | PIK3CA (0.46) | PIK3CAMTOR | |
| SCHEMBL753748 | 0.72 | PDE10A (0.36) | PIK3CAPDE10A | |
| SCHEMBL751435 | 0.72 | PIK3CA (0.61) | PIK3CAMTORPDE4BPDE4DPDE4A | |
| SCHEMBL4710579 | 0.70 | MKNK1 (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL753757 | 0.69 | GAA (0.38) | PIK3CAMTOR | |
| SCHEMBL10437261 | 0.68 | PDE10A (0.41) | PDE10APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL16010650 | 0.68 | PDE4B (0.38) | PIK3CAMTORPDE4BPDE4DPDE4A | |
| SCHEMBL2773798 | 0.66 | PIK3CA (0.61) | PIK3CAMTORPDE4BPDE4DPDE4A | |
| SCHEMBL753314 | 0.66 | PIK3CA (0.67) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | disclosed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | PIK3CA 1/4885MTOR 21/4885PDE10A 2496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.