Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 4/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551657 | 0.91 | GPR17 (0.36) | PTGESGPR17GRIN1 | |
| SCHEMBL7548647 | 0.80 | GPR17 (0.36) | PTGESGPR17FBP1GRIN1MAPT | |
| SCHEMBL7551410 | 0.79 | GPR17 (0.34) | PTGESGPR17FBP1 | |
| SCHEMBL7548270 | 0.76 | GPR17 (0.37) | PTGESGPR17FBP1PTGS2 | |
| SCHEMBL7551403 | 0.73 | GPR17 (0.35) | GPR17FBP1GRIN1 | |
| SCHEMBL7555556 | 0.73 | GPR17 (0.33) | GPR17FBP1PTGS2GRIN1MAPT | |
| Hydrochloric Acid SCHEMBL7554197 | 0.72 | GPR17 (0.32) | GPR17FBP1GRIN1MAPT | |
| SCHEMBL7551416 | 0.72 | GPR17 (0.34) | GPR17FBP1GRIN1 | |
| SCHEMBL7551654 | 0.71 | GPR17 (0.35) | GPR17GRIN1 | |
| SCHEMBL7548266 | 0.70 | GPR17 (0.39) | GPR17FBP1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |