Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.80 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.80 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787359 | 0.89 | MTOR (1.00) | MTORPIK3CAADORA2AADORA1CYP3A4 | |
| SCHEMBL11028589 | 0.88 | MTOR (0.73) | MTORPIK3CAADORA2AADORA1CYP3A4 | |
| SCHEMBL11030428 | 0.88 | MTOR (0.72) | MTORPIK3CAADORA2AADORA1MAPK13 | |
| SCHEMBL753941 | 0.87 | MTOR (0.61) | MTORPIK3CAMAPK13MAPK12MAPK11 | |
| SCHEMBL755161 | 0.84 | MTOR (0.71) | MTORPIK3CAADORA2AADORA1MAPK13 | |
| SCHEMBL2786633 | 0.83 | MTOR (0.76) | MTORPIK3CAADORA2AADORA1CYP3A4 | |
| SCHEMBL2785665 | 0.82 | MTOR (0.64) | MTORPIK3CAMAPK13MAPK12MAPK11 | |
| SCHEMBL756588 | 0.81 | MTOR (0.71) | MTORPIK3CA | |
| SCHEMBL2785390 | 0.80 | MTOR (0.61) | MTORPIK3CAMAPK13MAPK12MAPK11 | |
| SCHEMBL2787098 | 0.80 | MTOR (0.69) | MTORPIK3CAADORA2AADORA1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |