Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 16/20 | 0.72 |
| ▸ | AR | P10275 | 4/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | CCL2 | P13500 | 1/20 | 0.46 |
| ▸ | TAF1 | P21675 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812251 | 0.96 | BRD4 (0.67) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL751075 | 0.87 | BRD4 (0.79) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL745792 | 0.87 | BRD4 (0.79) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL746988 | 0.84 | BRD4 (1.00) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL3473630 | 0.84 | BRD4 (0.81) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL748087 | 0.83 | BRD4 (0.83) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL747361 | 0.82 | BRD4 (0.84) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL748540 | 0.81 | BRD4 (0.94) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL3474962 | 0.81 | BRD4 (0.83) | BRD4ARKCNH2CCL2TAF1 | |
| SCHEMBL745681 | 0.81 | BRD4 (0.83) | BRD4ARKCNH2CCL2TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396333-B1 | TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AND THEIR USES FOR PROSTATE CANCER | ASTRAZENECA AB (SE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2430024-A1 | [1,2,4]TRIAZOLO [4,3-B]PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | AstraZeneca AB (SE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131022-A1 | [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |