SCHEMBL7549779

SCHEMBL7549779

CC(CN(C)C)n1cc(-c2cncc(-c3ccccc3)c2)c2ccccc21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 7/20 0.54
FLT1 P17948 4/20 0.54
FLT4 P35916 4/20 0.54
DYRK1A Q13627 3/20 0.37
NFATC1 O95644 1/20 0.37
GSK3B P49841 1/20 0.37
CA12 O43570 2/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
DNM1 Q05193 2/20 0.33
KCNH2 Q12809 2/20 0.33
CHRNA7 P36544 1/20 0.33
ASH1L Q9NR48 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
HTR2A P28223 1/20 0.32
HRH1 P35367 1/20 0.32
MKNK1 Q9BUB5 1/20 0.32
MKNK2 Q9HBH9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7552885 0.91 KDR (0.51) KDRFLT1FLT4DYRK1ANFATC1
SCHEMBL7549609 0.89 KDR (0.49) KDRFLT1FLT4DYRK1ANFATC1
SCHEMBL7550587 0.89 KDR (0.49) KDRFLT1FLT4CYP11B1CYP11B2
SCHEMBL7557902 0.88 KDR (0.46) KDRFLT1FLT4DYRK1ANFATC1
SCHEMBL7548512 0.88 KDR (0.43) KDRFLT1FLT4
SCHEMBL7546221 0.88 KDR (0.48) KDRFLT1FLT4GSK3BCYP11B1
SCHEMBL7551876 0.87 KDR (0.72) KDRFLT1FLT4DYRK1ANFATC1
SCHEMBL7555466 0.86 PDE4B (0.46) KDRFLT1FLT4KCNH2CYP11B1
SCHEMBL7551901 0.84 KDR (0.42) KDRFLT1FLT4
SCHEMBL7549333 0.84 KDR (0.43) KDRFLT1FLT4KCNH2CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1147107-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2002-05-22 EP claimed
EP-1147107-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-10-24 EP claimed
WO-2000043393-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-07-27 WO claimed
EP-1147107-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2002-05-22 EP disclosed
EP-1147107-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-10-24 EP disclosed
US-6265403-B1 TYROSINE INHIBITORS MERCK & CO., INC. 2001-07-24 US disclosed
WO-2000043393-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-07-27 WO disclosed