Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.54 |
| ▸ | MTOR | P42345 | 11/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753916 | 0.85 | PIK3CA (0.61) | PIK3CAMTORCDK2MAPKAPK2 | |
| SCHEMBL750322 | 0.80 | PIK3CA (0.64) | PIK3CAMTORCDK2MAPKAPK2 | |
| SCHEMBL11026828 | 0.79 | PIK3CA (0.51) | PIK3CAMTORCDK2MAPKAPK2 | |
| SCHEMBL11026838 | 0.79 | PIK3CA (0.51) | PIK3CAMTORCDK2MAPKAPK2 | |
| SCHEMBL752881 | 0.79 | PIK3CA (0.60) | PIK3CAMTORCDK2MAPKAPK2 | |
| SCHEMBL755032 | 0.78 | PIK3CA (0.58) | PIK3CAMTORCDK2MAPKAPK2 | |
| SCHEMBL11030417 | 0.76 | PIK3CA (0.56) | PIK3CAMTORCDK2MAPKAPK2 | |
| SCHEMBL11025368 | 0.70 | PIK3CA (0.75) | PIK3CAMTOR | |
| SCHEMBL753636 | 0.69 | PIK3CA (0.61) | PIK3CAMTOR | |
| SCHEMBL2773478 | 0.68 | PIK3CA (0.47) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |