SCHEMBL7554583

SCHEMBL7554583

CCOC(=O)c1ccc(F)c(Cl)c1N(CC)S(C)(=O)=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
POLB P06746 1/20 0.40
MCOLN3 Q8TDD5 1/20 0.40
MAPT P10636 2/20 0.39
TSHR P16473 3/20 0.39
HSD17B10 Q99714 1/20 0.38
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
MAPK1 P28482 1/20 0.36
LMNA P02545 2/20 0.36
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
TLR4 O00206 1/20 0.36
KDM4E B2RXH2 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
WDR5 P61964 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7557970 0.87 TSHR (0.41) ALDH1A1POLBMCOLN3MAPTTSHR
SCHEMBL7557028 0.85 MAPT (0.43) ALDH1A1POLBMCOLN3MAPTTSHR
SCHEMBL7553893 0.83 CA1 (0.41) ALDH1A1MAPTTSHRHSD17B10CA12
SCHEMBL7550506 0.80 TSHR (0.47) ALDH1A1POLBMAPTTSHRHSD17B10
SCHEMBL7550819 0.78 TSHR (0.39) ALDH1A1MAPTTSHRHSD17B10CA12
SCHEMBL7556110 0.77 TSHR (0.41) ALDH1A1MAPTTSHRHSD17B10CA12
SCHEMBL7558430 0.77 MCOLN3 (0.51) ALDH1A1POLBMCOLN3MAPTTSHR
SCHEMBL27489734 0.76 POLB (0.34) ALDH1A1POLBMCOLN3MAPTTSHR
SCHEMBL7557752 0.74 TSHR (0.46) ALDH1A1POLBMCOLN3MAPTTSHR
SCHEMBL7556733 0.74 MEN1 (0.43) ALDH1A1MAPTTSHRHSD17B10CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0734380-B1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES AVENTIS AGRICULTURE LTD (GB) 2002-07-10 EP disclosed
US-6369270-B1 CHEMICAL INTERMEDIATES RHONE POULENC AGRICULTURE LIMITED (GB) 2002-04-09 US disclosed
US-6114538-A 2-POSITION OF BENZOY RING OF 4-BENZOYLISOXAZOLE DERIVATIVE IS SUBSTITUTED AND PARTICULARLY USED AGAINST MONOCOTYLEDONOUS WEEDS BY POST-EMEREGENECE APPLICATION RHONE POULENC AGRICULTURE LIMITED (GB) 2000-09-05 US disclosed
US-5998653-A CHEMICAL INTERMEDIATE FOR HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1999-12-07 US disclosed
US-5658858-A POSTEMERGENCE HERBICIDES RHONE-POULENC ARGRICULTURE LIMITED (GB) 1997-08-19 US disclosed
EP-0734380-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1996-10-02 EP disclosed
WO-1995016678-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1995-06-22 WO disclosed