⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2819145 | 0.68 | — | — | |
| Bromide SCHEMBL9840444 | 0.67 | — | — | |
| SCHEMBL5482556 | 0.61 | — | — | |
| SCHEMBL5442235 | 0.59 | — | — | |
| SCHEMBL11525533 | 0.54 | — | — | |
| SCHEMBL23187832 | 0.45 | — | — | |
| SCHEMBL7074396 | 0.45 | — | — | |
| SCHEMBL6365769 | 0.41 | — | — | |
| SCHEMBL9886121 | 0.41 | — | — | |
| SCHEMBL570870 | 0.40 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163240-A2 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-12-04 | — | — | EP | claimed |
| US-20240199609-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2024-06-20 | — | — | US | disclosed |
| US-11905283-B2 | Compounds and compositions for inhibiting the activity of SHP2 | NOVARTIS AG (CH) | 2024-02-20 | — | — | US | disclosed |
| EP-1184385-A1 | 1-[Alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-pyridin-4-yl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one derivatives | SANOFI-SYNTHELABO (FR) | 2002-03-06 | — | — | EP | disclosed |
| EP-0163240-A3 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1987-04-22 | — | — | EP | disclosed |
| EP-0183848-A1 | POLYAZAHETEROCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1986-06-11 | — | — | EP | disclosed |
| EP-0163240-A2 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-12-04 | — | — | EP | disclosed |
| EP-0163240-A2 | Dihydroimidazo[1,2-a]pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-12-04 | — | — | EP | disclosed |