Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019607 | 1.00 | LCK (0.59) | LCKJAK2JAK3MEN1NPC1 | |
| SCHEMBL7024412 | 0.94 | LCK (0.61) | LCKJAK2JAK3AKR1C3MKNK1 | |
| SCHEMBL7587154 | 0.94 | LCK (0.61) | LCKJAK2JAK3AKR1C3MKNK1 | |
| SCHEMBL7018638 | 0.92 | LCK (0.65) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7599669 | 0.89 | LCK (0.62) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7022463 | 0.89 | LCK (0.62) | LCKJAK2JAK3NPC1RAB9A | |
| SCHEMBL7592146 | 0.88 | LCK (0.63) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7019259 | 0.88 | LCK (0.63) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7023777 | 0.88 | LCK (0.59) | LCKJAK2JAK3MEN1KMT2A | |
| SCHEMBL7586650 | 0.88 | LCK (0.59) | LCKJAK2JAK3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |