Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12159553 | 0.75 | USP2 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL12657420 | 0.75 | NPC1 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL5255020 | 0.75 | USP2 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL10373039 | 0.75 | USP2 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL1265766 | 0.75 | USP2 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL24075123 | 0.75 | USP2 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL5387901 | 0.75 | USP2 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL12651544 | 0.75 | USP2 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| SCHEMBL1478153 | 0.75 | NPC1 (0.45) | USP2MEN1KMT2ANPC1ALPL | |
| Hydrochloric Acid SCHEMBL1003531 | 0.73 | USP2 (0.44) | USP2MEN1KMT2ANPC1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407093-B1 | (3,4-DIHYDRO-2H-BENZOTHIOPYRAN-4-YL)-HOMOPIPERAZINE DERIVATIVES; ANTIISCHEMIC AGENTS; ALZHEIMER*S AND PARKINSON*S DISEASE, AIDS RELATED DEMENTIA, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS | ASTRAZENECA UK LIMITED (GB) | 2002-06-18 | — | — | US | disclosed |
| EP-1198463-A2 | COMPOUNDS FOR USE IN TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2002-04-24 | — | — | EP | disclosed |
| WO-2000078751-A2 | COMPOUNDS FOR USE IN TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |
| EP-1051416-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999038863-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 1999-08-05 | — | — | WO | disclosed |