Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.43 |
| ▸ | TRPC7 | Q9HCX4 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670671 | 0.94 | TRPC3 (0.43) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL7529385 | 0.88 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL5752224 | 0.88 | TRPC3 (0.43) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL6170828 | 0.86 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL6171325 | 0.86 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL7469105 | 0.85 | TRPC3 (0.44) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL7463352 | 0.84 | GRIN2B (0.46) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL7468591 | 0.82 | TRPC3 (0.42) | MAPK13MAPK12MAPK11MAPK14TRPC3 | |
| SCHEMBL7679585 | 0.82 | GRIN2B (0.46) | TRPC3TRPC7CYP3A4F2RTRPV4 | |
| SCHEMBL7678065 | 0.79 | MAPK14 (0.62) | MAPK13MAPK12MAPK11MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131314-A4 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-05-02 | — | — | EP | disclosed |
| US-6350744-B1 | PYRMIDINE OR PYRIDINE DERIVATIVES; ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS; CACHEXIA TREATMENT; INTERLEUKIN AND TUMOR NECROSIS FACTOR INHIBITORS | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |
| EP-1131314-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031065-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2000-06-02 | — | — | WO | disclosed |