Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.65 |
| ▸ | TLK2 | Q86UE8 | 12/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7556214 | 1.00 | CHEK1 (0.65) | CHEK1TLK2CHEK2CDK1SRC | |
| SCHEMBL7554877 | 0.87 | CHEK1 (0.63) | CHEK1TLK2CHEK2CDK1SRC | |
| SCHEMBL7554878 | 0.87 | CHEK1 (0.63) | CHEK1TLK2CHEK2CDK1SRC | |
| SCHEMBL7557254 | 0.85 | CHEK1 (0.65) | CHEK1TLK2CHEK2CDK1SRC | |
| SCHEMBL7556835 | 0.84 | CHEK1 (0.66) | CHEK1TLK2CHEK2CDK1SRC | |
| SCHEMBL7556831 | 0.84 | CHEK1 (0.66) | CHEK1TLK2CHEK2CDK1SRC | |
| SCHEMBL8530207 | 0.83 | TLK2 (0.53) | TLK2JAK3GSK3BPAK4 | |
| SCHEMBL7550675 | 0.83 | CHEK1 (0.67) | CHEK1TLK2CHEK2CDK1SRC | |
| SCHEMBL7550684 | 0.83 | CHEK1 (0.67) | CHEK1TLK2CHEK2CDK1SRC | |
| Hydrochloric Acid SCHEMBL8827979 | 0.82 | CHEK1 (0.66) | CHEK1TLK2CHEK2CDK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715628-B1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2002-10-02 | — | — | EP | claimed |