Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.71 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30831649 | 0.86 | EPHX1 (0.73) | EPHX1CHRM1UBE2N | |
| SCHEMBL28605746 | 0.85 | EPHX1 (0.71) | EPHX1CTSBCHRM1UBE2NPOLB | |
| SCHEMBL29609668 | 0.85 | EPHX1 (0.71) | EPHX1CTSBCHRM1UBE2NPOLB | |
| SCHEMBL1516139 | 0.84 | EPHX1 (1.00) | EPHX1CHRM1UBE2NPOLB | |
| SCHEMBL7556577 | 0.83 | EPHX1 (0.51) | EPHX1CTSBPTGS2 | |
| SCHEMBL8620330 | 0.82 | EPHX1 (0.96) | EPHX1CHRM1UBE2NPOLBMEN1 | |
| SCHEMBL29609727 | 0.82 | EPHX1 (0.71) | EPHX1CHRM1MEN1KMT2A | |
| SCHEMBL29609793 | 0.82 | EPHX1 (0.71) | EPHX1CHRM1UBE2N | |
| SCHEMBL29609873 | 0.82 | EPHX1 (0.71) | EPHX1CTSBMEN1KMT2A | |
| SCHEMBL28605618 | 0.82 | EPHX1 (0.71) | EPHX1CHRM1UBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946495-B1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6353128-B1 | FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK. | ELI LILLY AND COMPANY | 2002-03-05 | — | — | US | disclosed |