Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCND3 | P30281 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252137 | 0.86 | KDR (1.00) | KDRFGFR1LCK | |
| SCHEMBL7553519 | 0.82 | KDR (0.75) | KDRFGFR1CHEK1LCKCDK4 | |
| SCHEMBL7554473 | 0.81 | KDR (0.75) | KDRFGFR1CHEK1LCKCDK4 | |
| SCHEMBL5247993 | 0.73 | KDR (1.00) | KDRFGFR1CHEK1LCKCDK4 | |
| SCHEMBL5247997 | 0.73 | KDR (1.00) | KDRFGFR1CHEK1LCKCDK4 | |
| SCHEMBL7556842 | 0.73 | KDR (0.43) | KDR | |
| SCHEMBL2457430 | 0.72 | HPGD (0.49) | KDRFGFR1CHEK1LCKCDK4 | |
| SCHEMBL2457428 | 0.72 | HPGD (0.49) | KDRFGFR1CHEK1LCKCDK4 | |
| SCHEMBL5249741 | 0.72 | KDR (1.00) | KDRFGFR1CHEK1LCKCDK4 | |
| SCHEMBL5249744 | 0.72 | KDR (1.00) | KDRFGFR1CHEK1LCKCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218348-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001002369-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |