SCHEMBL7557199

SCHEMBL7557199

CC(=O)NCCC1(C(=O)N[C@@H](Cc2ccc(NC[C@@H](N)C(=O)c3ccc(Cl)cc3)cc2)C(=O)O)CCCC1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 20/20 0.60
ITGA4 P13612 20/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7410158 0.90 ITGB1 (0.59) ITGB1ITGA4
SCHEMBL6654976 0.85 ITGB1 (0.70) ITGB1ITGA4
SCHEMBL7412380 0.83 ITGB1 (0.61) ITGB1ITGA4
SCHEMBL6632016 0.78 ITGB1 (0.69) ITGB1ITGA4
SCHEMBL6628815 0.78 ITGB1 (0.66) ITGB1ITGA4
SCHEMBL6631475 0.78 ITGB1 (0.69) ITGB1ITGA4
SCHEMBL6630177 0.76 ITGB1 (0.63) ITGB1ITGA4
SCHEMBL6627144 0.73 ITGB1 (0.62) ITGB1ITGA4
SCHEMBL6630847 0.73 ITGB1 (0.61) ITGB1ITGA4
SCHEMBL6673062 0.71 ITGB1 (0.95) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1005446-A1 N-AROYLPHENYLALANINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-06-07 EP disclosed
WO-1999010313-A1 N-AROYLPHENYLALANINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 1999-03-04 WO disclosed