Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.74 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554932 | 0.84 | KDR (0.82) | KDRFGFR1LCK | |
| SCHEMBL5251696 | 0.83 | KDR (1.00) | KDRFGFR1LCK | |
| SCHEMBL5247450 | 0.82 | KDR (1.00) | KDRFGFR1LCK | |
| SCHEMBL7549897 | 0.81 | KDR (0.81) | KDRFGFR1LCK | |
| SCHEMBL5246405 | 0.80 | KDR (1.00) | KDRFGFR1LCK | |
| SCHEMBL5307470 | 0.80 | KDR (0.75) | KDRFGFR1LCK | |
| SCHEMBL5254116 | 0.80 | KDR (0.77) | KDRFGFR1LCK | |
| SCHEMBL5250940 | 0.80 | KDR (1.00) | KDRFGFR1LCK | |
| SCHEMBL5250168 | 0.80 | KDR (0.77) | KDRFGFR1LCK | |
| SCHEMBL5254038 | 0.79 | KDR (1.00) | KDRFGFR1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218348-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001002369-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |