Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515631 | 0.90 | PDE7A (0.43) | PDE7AALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL7511743 | 0.89 | TP53 (0.51) | PDE7ATP53LMNAPOLBKMT2A | |
| SCHEMBL7517191 | 0.89 | TP53 (0.51) | PDE7ATP53LMNAPOLBKMT2A | |
| SCHEMBL7517887 | 0.86 | KMT2A (0.52) | ALDH1A1SMN1; SMN2TP53LMNAPOLB | |
| SCHEMBL6618392 | 0.85 | TP53 (0.56) | ALDH1A1TP53LMNAPOLBKMT2A | |
| SCHEMBL7507712 | 0.85 | TP53 (0.53) | PDE7AALDH1A1SMN1; SMN2TP53POLB | |
| SCHEMBL7507708 | 0.85 | TP53 (0.53) | PDE7AALDH1A1SMN1; SMN2TP53POLB | |
| SCHEMBL6618396 | 0.85 | TP53 (0.56) | ALDH1A1TP53LMNAPOLBKMT2A | |
| SCHEMBL7509354 | 0.83 | PDE7A (0.41) | PDE7AALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL7509348 | 0.83 | PDE7A (0.41) | PDE7AALDH1A1SMN1; SMN2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |