Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.71 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.71 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL752642 | 0.89 | MTOR (0.69) | MTORPIK3CACACNA1GCACNA1HCACNA1I | |
| Trifluoroacetic Acid SCHEMBL754788 | 0.86 | MTOR (0.62) | MTORPIK3CACSNK1DCACNA1GCACNA1H | |
| SCHEMBL11029468 | 0.85 | MTOR (0.76) | MTORPIK3CACSNK1DCSNK1EKDM4E | |
| SCHEMBL2787610 | 0.83 | MTOR (1.00) | MTORPIK3CACSNK1DCSNK1EADORA1 | |
| SCHEMBL756436 | 0.83 | MTOR (0.76) | MTORPIK3CAMKNK1CSNK1DCSNK1E | |
| SCHEMBL752869 | 0.78 | MTOR (0.70) | MTORPIK3CA | |
| SCHEMBL751580 | 0.75 | MTOR (0.71) | MTORPIK3CA | |
| SCHEMBL755585 | 0.74 | MTOR (0.81) | MTORPIK3CAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11031102 | 0.74 | MTOR (0.77) | MTORPIK3CAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL753664 | 0.73 | MTOR (0.74) | MTORPIK3CAADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | claimed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |