SCHEMBL7560974

SCHEMBL7560974

COc1cc(C(=O)N(C)c2ccc(C)cc2OCCCCCNC(=O)OC(C)(C)C)ccc1NC(=O)c1cccc2[nH]c(C)nc12

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.35
KDM4E B2RXH2 3/20 0.35
MAPT P10636 3/20 0.35
NPSR1 Q6W5P4 3/20 0.35
STING1 Q86WV6 2/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
TDP1 Q9NUW8 2/20 0.34
IRAK4 Q9NWZ3 3/20 0.34
BRD4 O60885 1/20 0.34
GPBAR1 Q8TDU6 1/20 0.33
TP53 P04637 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7475032 0.91 IRAK4 (0.36) MAPTIRAK4BRD4TP53
SCHEMBL7964884 0.88 BRD4 (0.35) KDM4EIRAK4BRD4TSHR
SCHEMBL7964830 0.88 IRAK4 (0.37) MAPTIRAK4TP53
SCHEMBL7607734 0.88 BRD4 (0.35) MAPTIRAK4BRD4TP53TSHR
SCHEMBL7482373 0.88 BRD4 (0.34) MAPTIRAK4BRD4TSHR
Hydrochloric Acid SCHEMBL7610476 0.88 IRAK4 (0.36) MAPTIRAK4TP53
SCHEMBL7478105 0.87 IRAK4 (0.37) MAPTIRAK4TP53
SCHEMBL7564594 0.87 RXFP1 (0.37) MAPTIRAK4TP53TSHR
SCHEMBL7483103 0.87 BRD4 (0.36) MAPTSTING1CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7968769 0.87 IRAK4 (0.37) MAPTIRAK4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed
EP-0946519-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 EP disclosed
WO-1998024771-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-11 WO disclosed