Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GRM5 | P41594 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13210615 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1GRM5HPGDL3MBTL1 | |
| SCHEMBL1018513 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2ALDH1A1GRM5HPGDL3MBTL1 | |
| SCHEMBL3227298 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1GRM5HPGDPHGDH | |
| SCHEMBL1017672 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1GRM5HPGDL3MBTL1 | |
| SCHEMBL6742231 | 0.81 | SMN1; SMN2 (0.83) | SMN1; SMN2ALDH1A1GRM5HPGDL3MBTL1 | |
| SCHEMBL30445048 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1GRM5HPGDL3MBTL1 | |
| SCHEMBL17559403 | 0.79 | SMN1; SMN2 (0.81) | SMN1; SMN2ALDH1A1GRM5HPGDL3MBTL1 | |
| SCHEMBL2999369 | 0.79 | PHGDH (0.69) | SMN1; SMN2ALDH1A1HPGDL3MBTL1POLB | |
| SCHEMBL28872982 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1GRM5HPGDPOLB | |
| SCHEMBL15008288 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1GRM5HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020068746-A1 | Pyrrolo[2,3-d]pyrimidine compounds | PFIZER INC. | 2002-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068746-A1 | Pyrrolo[2,3-d]pyrimidine compounds | JAK1, CDK2, JAK3 | SMN1; SMN2 4219/4885ALDH1A1 1719/4885GRM5 3467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.